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… So I built a lab to do that. And then yes, we had several targets– mechanistic enzymology targets and biosynthetic gene cluster targets that we did. DAN UDWARY: You were the first person I … discovering and expressing cryptic metabolic pathways” On target identification and cancer biology: “Apoptolidin …

… Illumina and PacBio sequencing platforms. **Operating Hours target is based on 98% of the total available hours.   FY … Illumina and PacBio sequencing platforms. **Operating Hours target is based on 98% of the total available hours.   FY … Illumina and PacBio sequencing platforms. **Operating Hours target is based on 98% of the total available hours.   FY …

… a description of the product and deliverables as well as target cycle times from sample receipt to completion of …

… has developed, tested and deployed a pipeline to first target cells from communities of uncultivated microbes, and … remains unexplored and uncultivated. Developing a more targeted genomic approach would allow researchers to focus … a one probe adds one fluorescent molecule when bound to a target, HCR-FISH attaches multiple fluorescent tags to a …

… as a new type of medicine that will open up a new year for targeted anti cancer drug discovery. DAN: Yeah, great. Are … the chemistry needed to direct this unstable warhead to its target. As we discuss in the podcast, enediynes are often …

… survival. Those molecules, over evolutionary time, become targeted to certain biological systems in the target organism. So, if you want to restrict a fish from … make a compound, you want that to be effective by hitting a target in a fish. Well, what is that target? We didn’t know, …

… can lead to a particular high activity towards a particular target. That’s why an antibiotic has to be a particular structure– because we are targeting a very – specificity – a particular target and only one structure will do the job. So the …

… The Secondary Metabolites Program targets the vast and underexplored reservoir of secondary … (RIViT-seq) to identify RNA polymerase-sigma factor targets, and have expanded the sigma factor-target pairs twofold. We are also utilizing DNA-Affinity …

… complemented with single-cell resolution assays that can be targeted towards specific phages and/or hosts. To that end, … Paul, B.G., Bagby, S.C. et al. (2021) Ecology and molecular targets of hypermutation in the global microbiome. Nat …